The protein Treacle turned out to be the main organizer of DNA repair in the nucleolus.
Anna Salnikova News Feed Editor
AI Illustration created with the help of AI
Scientists from the Institute of Gene Biology of the Russian Academy of Sciences, the Institute of Bioorganic Chemistry of the Russian Academy of Sciences, and Moscow State University have found that the Treacle protein plays a key role in protecting the genes responsible for ribosome assembly from damage. It forms a signaling platform for precise DNA repair. In the course of the experiment, researchers artificially disabled the gene that synthesizes Treacle in a culture of human cells. This led to the disappearance of another protein — TOPBP1, which regulates DNA repair. Without Treacle, the cell switches to a less accurate repair pathway, which can lead to errors.
Treacle turned out to be not just an auxiliary but the main organizer of the "emergency team" in the nucleolus. Its mutations are associated with Treacher Collins syndrome — a rare hereditary disease that causes developmental disorders of the skull and face. In the future, scientists plan to study the role of Treacle in cancer cells. It is assumed that temporary disabling of the protein may make the tumor more vulnerable to chemotherapy, while its stimulation may protect healthy cells. However, for now, this is about fundamental research, not a ready-made treatment method.
More news about the event:
The Treacle protein turned out to be the main organizer of DNA repair in the nucleolus
Anna Salnikova News Feed Editor
AI Illustration created with the help of AI
Scientists from the Institute of Gene Biology of the Russian Academy of Sciences, the Institute of Bioorganic Chemistry of the Russian Academy of Sciences, and Moscow State University have found, 11:07 07.07.2026 ProKazan.Ru - Kazan
The Treacle protein manages the "emergency service" of DNA repair
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Scientists from the Institute of Gene Biology of the Russian Academy of Sciences, the Institute of Bioorganic Chemistry of the Russian Academy of Sciences, and Moscow State University have found out how cells protect the genes responsible for ribosome assembly from damage. 10:36 07.07.2026 ProKazan.Ru - Kazan
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The protein Treacle turned out to be the main organizer of DNA repair in the nucleolus.
Anna Salnikova News Feed Editor AI Illustration created with the help of AI Scientists from the Institute of Gene Biology of the Russian Academy of Sciences, the Institute of Bioorganic Chemistry of the Russian Academy of Sciences, and Moscow State University have found out, 07.07.2026. ProKazan.Ru. Republic of Tatarstan. Kazan.